Basic Information
ID DDInter1347 and DDInter1932
Interaction INTERVAL: The use of live, attenuated cholera vaccine with systemic antibiotics may result in a diminished immunologic response to the vaccine. Some antibiotics may be active against the vaccine strain of Vibrio cholerae, thereby preventing a sufficient degree of multiplication to occur in order to induce a protective immune response.
Management Live, attenuated cholera vaccine should not be administered during or for at least 14 days after treatment with systemic antibiotics.
References [1] "Product Information. Vaxchora (cholera vaccine, live)." PaxVax, Miami, FL. [2] "Product Information. Vaxchora (cholera vaccine, live)." PaxVax, Miami, FL.
Alternative for Oritavancin J01X
Lefamulin Methenamine
Alternative for Vibrio cholerae CVD 103-HgR strain live antigen (live) -
Potential Metabolism Interactions
Substrate-Substrate Interaction：If more than one drug is metabolized by the same CYP, it is possible that its metabolism is inhibited because of the competition between the drugs. That means, it can be useful to lower the dosage of the drugs in the drug-cocktail because they remain longer in the organism than in monotherapy.
Inhibitor-Inhibitor Interaction：Combining two or more inhibitors of one CYP, should be compensated by lowering the dosage of these drugs because the metabolism is reduced and the drugs remain longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.
Inhibitor-Substrate Interaction：Combining drugs that have inhibitory effect and are substrates of one particular CYP, should be compensated by lowering the dosage. They rest longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.