Basic Information
ID DDInter1032
Drug Type small molecule
Molecular Formula C28H45NO5S
Molecular Weight 507.730
CAS Number 1061337-51-6
Description Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus.[A183206] Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August 2019.[L8093] This drug is the first semi-synthetic pleuromutilin that has been designed for systemic administration. Lefamulin features a novel mechanism of action that shows benefit against resistant bacteria that cause pneumonia.[A183161] The chemical structure of lefamulin contains a tricyclic mutilin core that is necessary for some of its antimicrobial activity.[A183167]
ATC Classification J01XX12
IUPAC Name (1S,2R,3S,4S,6R,7R,8R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxotricyclo[5.4.3.0^{1,8}]tetradecan-6-yl 2-{[(1R,2R,4R)-4-amino-2-hydroxycyclohexyl]sulfanyl}acetate
InChI KPVIXBKIJXZQJX-CSOZIWFHSA-N
Canonical SMILES [H][C@@]12C(=O)CC[C@]11CCC(C)[C@@]2(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]1C)OC(=O)CS[C@@H]1CC[C@@H](N)C[C@H]1O
Useful Links DrugBank PubChem Substance BindingDB Wikipedia ChEMBL
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