Basic Information
ID DDInter139 and DDInter2139
Interaction Gold salts and antimalarial agents have the potential to cause blood dyscrasias and other severe adverse effects.
Management Concomitant use is generally considered to be contraindicated. Caution should be exercised if these drugs must be used together.
References [1] "Product Information. Ridaura (auranofin)." SmithKline Beecham (2001): [2] "Product Information. Solganal (aurothioglucose)." Schering Corporation (2001): [3] "Product Information. Myochrysine (gold sodium thiomalate)." Merck & Co., Inc (2022):
Alternative for Auranofin M01C
Sodium aurothiomalate Aurothioglucose Penicillamine
Alternative for Quinacrine P01A
Furazolidone Trimetrexate Nitazoxanide Atovaquone
Potential Metabolism Interactions
Substrate-Substrate Interaction：If more than one drug is metabolized by the same CYP, it is possible that its metabolism is inhibited because of the competition between the drugs. That means, it can be useful to lower the dosage of the drugs in the drug-cocktail because they remain longer in the organism than in monotherapy.
Inhibitor-Inhibitor Interaction：Combining two or more inhibitors of one CYP, should be compensated by lowering the dosage of these drugs because the metabolism is reduced and the drugs remain longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.
Inhibitor-Substrate Interaction：Combining drugs that have inhibitory effect and are substrates of one particular CYP, should be compensated by lowering the dosage. They rest longer in the organism than in monotherapy. Not adapting the dosage bears the risk of even more side effects.