Drugs Information:
Inebilizumab
Basic Information
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| ID | DDInter922 | |
| Drug Type | biotech | |
| Protein Chemical Formula | None | |
| Protein Average Weight | 149000.000 | |
| CAS Number | 1299440-37-1 | |
| Description | Inappropriate growth of or self-directed antibody production by B-cells is the etiological underpinning of a variety of conditions, including the multiple sclerosis-like neurological condition neuromyelitis optica spectrum disorder (NMOSD).[A214283, A214286] Inebilizumab is a humanized afucosylated monoclonal IgG1 antibody directed against the broadly expressed B-cell surface antigen CD19. Inebilizumab is cytolytic, resulting in B-cell depletion and offering therapeutic benefit to patients suffering from NMOSD. Compared to the anti-CD20 antibody [rituximab], which is also used to treat NMOSD, inebilizumab has broader specificity.[A214280, A214289, A214292, A214295, A214298, A214301] Inebilizumab was granted FDA approval on June 11, 2020, for the treatment of anti-aquaporin 4 positive NMOSD patients.[L14315] Given its mechanism of action and good safety profile, it may prove useful in the treatment of other conditions linked to autoimmune antibody production or B-cell malignancies.[A214280, A214295] | |
| ATC Classification | L04AA47 | |
| Sequences | None | |
| Useful Links | DrugBank PubChem Substance Wikipedia | |
Interactions with
Inebilizumab
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Interactions with diseases
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Interactions with foods
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Interactions with compound preparation
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