Basic Information
ID DDInter852
Drug Type small molecule
Molecular Formula C26H30Cl2F3NO
Molecular Weight 500.424
CAS Number 69756-53-2
Description Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferentially block open and inactivated HERG channels leading to some degree of cardiotoxicity.
ATC Classification P01BX01
IUPAC Name 3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]propan-1-ol
InChI FOHHNHSLJDZUGQ-UHFFFAOYSA-N
Canonical SMILES CCCCN(CCCC)CCC(O)C1=C2C=CC(=CC2=C2C=C(Cl)C=C(Cl)C2=C1)C(F)(F)F
Useful Links DrugBank ChEBI PubChem Substance KEGG Compound ChemSpider BindingDB PharmGKB Therapeutic Targets Database Wikipedia ChEMBL
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Multi-DRUG trade Multi-DRUG Drug type Warning Note