ID	DDInter823
	Drug Type	biotech
	Protein Chemical Formula	(C5H9NO4•C3H7NO2•C6H14N2O2•C9H11NO3)x•xC2H4O2
	Protein Average Weight	7000.000
	CAS Number	28704-27-0
	Description	Glatiramer acetate is a mix of synthetic polypeptides that includes L-glutamic acid, L-alanine, L-tyrosine, and L-lysine at an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively.[L41940] Since glatiramer acetate is a heterogeneous drug, there is limited information about its physicochemical properties.[A248870] Originally, glatiramer acetate was designed as a stimulant of myelin basic protein (MBP), a myelin antigen involved in the development of multiple sclerosis (MS), to induce experimental autoimmune encephalitis (MS animal model).[A248870] However, the opposite was observed. Glatiramer acetate exhibits several immunomodulatory effects and reduces the relapse rate of relapsing-remitting multiple sclerosis (RRMS) by 30%.[A248870] Along with [human interferon beta], [teriflunomide], and [dimethyl fumarate], glatiramer acetate is a first-line drug for patients with MS.[A248880] It was approved by the FDA in 1996, and a generic version became available in 2017.
	ATC Classification	L03AX13
Sequences	>Example Glatiramer peptide EAYKAAEKAYAAKEAAKEAAKAKAEKKAAYAKAKAAKYEKKAKKAAAEYKKK
Useful Links	DrugBank PubChem Substance PharmGKB Therapeutic Targets Database Wikipedia ChEMBL