Basic Information
ID DDInter791
Drug Type small molecule
Molecular Formula C9H17NO2
Molecular Weight 171.237
CAS Number 60142-96-3
Description Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid ([GABA]) that was first approved for use in the United States in 1993.[L8717] It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures[A186277,A186143] - today it is also widely used to treat neuropathic pain.[A14097,A186179] Gabapentin has some stark advantages as compared with other anti-epileptics, such as a relatively benign adverse effect profile, wide therapeutic index, and lack of appreciable metabolism making it unlikely to participate in pharmacokinetic drug interactions.[A186143,A185981,L8717]. It is structurally and functionally related to another GABA derivative, [pregabalin].
ATC Classification N03AX12
IUPAC Name 2-[1-(aminomethyl)cyclohexyl]acetic acid
InChI UGJMXCAKCUNAIE-UHFFFAOYSA-N
Canonical SMILES NCC1(CC(O)=O)CCCCC1
Useful Links DrugBank ChEBI PubChem Substance KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Wikipedia ChEMBL ZINC
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