Basic Information
ID DDInter79
Drug Type small molecule
Molecular Formula C20H25ClN2O5
Molecular Weight 408.876
CAS Number 88150-42-9
Description Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and cardiac conduction abnormalities than other calcium channel blockers [A175327]. Amlodipine is commonly used in the treatment of high blood pressure and angina. Amlodipine has antioxidant properties and an ability to enhance the production of nitric oxide (NO), an important vasodilator that decreases blood pressure [A175321]. The option for single daily dosing of amlodipine is an attractive feature of this drug [FDA label].
ATC Classification C09XA54 C10BX07 C09BB03 C09BB04 C07FB07 C09DB06 C10BX18 C07FB12 C09DB05 C09XA53 C10BX03 C07FB13 C08CA01 C09BX04 C09BX03 C09DB04 C09DX03 C08GA02 C09DB07 C09DX06 C09BX01 C10BX11 C09DB02 C10BX09 C08CA51 C09DX01 C09DB09 C09DB01 C10BX14 C09BB07 C09DX07
IUPAC Name 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
InChI HTIQEAQVCYTUBX-UHFFFAOYSA-N
Canonical SMILES CCOC(=O)C1=C(COCCN)NC(C)=C(C1C1=CC=CC=C1Cl)C(=O)OC
Useful Links DrugBank ChEBI PubChem Substance KEGG Compound KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Wikipedia ChEMBL
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