2D 3D
	ID	DDInter717
	Drug Type	small molecule
	Molecular Formula	C12H16F3N
	Molecular Weight	231.257
	CAS Number	458-24-2
	Description	Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients typically display delayed development and neurocognitive impairment.[A214694, A214709, A214712, A214715] Fenfluramine is a serotonergic phenethylamine originally used as an appetite suppressant until concerns regarding cardiotoxicity in obese patients lead to its withdrawal from the market in 1997.[A214694, A214718, A11906] Through its ability to modulate neurotransmission, fenfluramine has reemerged as an effective therapy against pharmacoresistant seizures, such as those involved in Dravet syndrome.[A214688, A214691, A214700] Fenfluramine was granted initial FDA approval in 1973 prior to its withdrawal; it was granted a new FDA approval on June 25, 2020, for treatment of patients with Dravet syndrome and Lennox-Gastaut syndrome through the restricted FINTEPLA REMS program. It is currently sold under the name FINTEPLA® by Zogenix INC.[L14522]
	ATC Classification	A08AA02 N03AX26
IUPAC Name	ethyl({1-[3-(trifluoromethyl)phenyl]propan-2-yl})amine
InChI	DBGIVFWFUFKIQN-UHFFFAOYSA-N
Canonical SMILES	CCNC(C)CC1=CC=CC(=C1)C(F)(F)F
Useful Links	DrugBank ChEBI PubChem Substance KEGG Compound KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Wikipedia ChEMBL