Basic Information
ID DDInter712
Drug Type small molecule
Molecular Formula C8H15N7O2S3
Molecular Weight 337.445
CAS Number 76824-35-6
Description Famotidine is a competitive histamine-2 (H2) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children.[L11166] Compared to other H2 receptor antagonists, famotidine displays high selectivity towards this receptor; in a study consisting of healthy volunteers and patients with acid hypersecretory disease, famotidine was about 20 to 50 times more potent at inhibiting gastric acid secretion than [cimetidine] and eight times more potent than [ranitidine] on a weight basis.[A189462] Famotidine is used in various over-the-counter and off-label uses.[L11166] While oral formulations of famotidine are more commonly used, the intravenous solution of the drug is available for use in hospital settings.[L11142]
ATC Classification A02BA03 A02BA53
IUPAC Name 3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N'-sulfamoylpropanimidamide
InChI XUFQPHANEAPEMJ-UHFFFAOYSA-N
Canonical SMILES NC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1
Useful Links DrugBank ChEBI PubChem Substance KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Wikipedia ChEMBL ZINC
Interactions with Famotidine
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Interactions with compound preparation
Multi-DRUG trade Multi-DRUG Drug type Warning Note