Basic Information
ID DDInter650
Drug Type small molecule
Molecular Formula C10H15NO
Molecular Weight 165.232
CAS Number 299-42-3
Description Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine].[A193698] Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepinephrine from sympathetic neurons, inhibiting norepinephrine reuptake and displacing more norepinephrine from storage vesicles.[A193650,L12972] Ephedrine is used for its vasoconstrictive, positive chronotropic, and positive inotropic effects.[L12972] Ephedrine and [phenylephrine] are still used to treat hypotension, but their use in other indications has decreased due to the development of more selective adrenergic agonists.[A193701,A193704,L12975] Ephedrine was granted a type 7 FDA Approval on 29 April 2016.[L12975]
ATC Classification S01FB02 R01AB05 C01CA26 R03CA02 A08AA56 R01AA03
IUPAC Name (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol
InChI KWGRBVOPPLSCSI-WPRPVWTQSA-N
Canonical SMILES CN[C@@H](C)[C@H](O)C1=CC=CC=C1
Useful Links DrugBank ChEBI PubChem Substance KEGG Compound KEGG Drug ChemSpider PharmGKB Therapeutic Targets Database Guide to Pharmacology Wikipedia ChEMBL ZINC
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