Basic Information
ID DDInter564
Drug Type small molecule
Molecular Formula C6H8O4
Molecular Weight 144.125
CAS Number 624-49-7
Description Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress.[L43752] Dimethyl fumarate is marketed under the brand name Tecfidera, and it was the third oral disease-modifying agent for multiple sclerosis approved by the FDA, following [fingolimod] and [teriflunomide].[A253917] Prior to its FDA approval, dimethyl fumarate had been used in Germany for treatment of psoriasis.[A253917]
ATC Classification L04AX07
IUPAC Name 1,4-dimethyl (2E)-but-2-enedioate
InChI LDCRTTXIJACKKU-ONEGZZNKSA-N
Canonical SMILES [H]\C(=C(\[H])C(=O)OC)C(=O)OC
Useful Links DrugBank ChEBI PubChem Substance KEGG Drug ChemSpider BindingDB PharmGKB Wikipedia ChEMBL ZINC
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