2D 3D
	ID	DDInter537
	Drug Type	small molecule
	Molecular Formula	C14H11Cl2NO2
	Molecular Weight	296.149
	CAS Number	15307-86-5
	Description	Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and inflammation from a variety of causes. Diclofenac was the product of rational drug design based on the structures of [phenylbutazone], [mefenamic acid], and [indomethacin].[A180796] The addition of two chlorine groups in the ortho position of the phenyl ring locks the ring in maximal torsion which appears to be related to increased potency. It is often used in combination with [misoprostol] to prevent NSAID-induced gastric ulcers. Diclofenac was first approved by the FDA in July 1988 under the trade name Voltaren, marketed by Novartis (previously Ciba-Geigy).[L7360]
	ATC Classification	S01CC01 S01BC03 M01AB55 M02AA15 M01AB05 D11AX18
IUPAC Name	2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid
InChI	DCOPUUMXTXDBNB-UHFFFAOYSA-N
Canonical SMILES	OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl
Useful Links	DrugBank ChEBI PubChem Substance KEGG Compound KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Guide to Pharmacology Wikipedia ChEMBL ZINC