Basic Information
ID DDInter530
Drug Type small molecule
Molecular Formula C15H11I4NO4
Molecular Weight 776.870
CAS Number 51-49-0
Description The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory effects on cell metabolism.
ATC Classification C10AX01
IUPAC Name (2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
InChI XUIIKFGFIJCVMT-GFCCVEGCSA-N
Canonical SMILES N[C@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)C(O)=O
Useful Links DrugBank ChEBI PubChem Substance ChemSpider BindingDB PharmGKB Wikipedia ChEMBL ZINC
Interactions with Dextrothyroxine
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