Basic Information
ID DDInter481
Drug Type small molecule
Molecular Formula C19H19ClN6O2
Molecular Weight 398.850
CAS Number 1297538-32-9
Description Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists.[A189063] Though prior treatment for prostate cancer has been successful for these patients, the cancer eventually progresses to become resistant to existing therapies. This warrants further treatment. The goal of treatment with darolutamide is to delay the progression of prostate cancer to metastatic disease, increasing quality of life and life expectancy for those with advanced prostate cancer.[A189054,A189063] Darolutamide was developed by Bayer HealthCare Pharmaceuticals Inc. and approved by the FDA on July 30th, 2019.[L10887]
ATC Classification L02BB06
IUPAC Name N-[(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide
InChI BLIJXOOIHRSQRB-PXYINDEMSA-N
Canonical SMILES C[C@@H](CN1C=CC(=N1)C1=CC=C(C#N)C(Cl)=C1)NC(=O)C1=NNC(=C1)C(C)O
Useful Links DrugBank PubChem Substance ChemSpider BindingDB Wikipedia ChEMBL
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Multi-DRUG trade Multi-DRUG Drug type Warning Note