Drugs Information:
Dalbavancin
Basic Information
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| ID | DDInter467 | |
| Drug Type | small molecule | |
| Molecular Formula | None | |
| Molecular Weight | - | |
| CAS Number | 171500-79-1 | |
| Description | Dalbavancin is a second-generation lipoglycopeptide antibiotic that was designed to improve on the natural glycopeptides currently available, such as vancomycin and teicoplanin [A4072, A4073]. Modifications from these older glycoprotein classes facilitated a similar mechanism of action for dalbavancin but with increased activity and once-weekly dosing [FDA Label, F2356, A4072, A4073]. Its use is indicated for the treatment of acute bacterial skin and skin structure infections (ABSSSI) caused by the following gram-positive microorganisms: Staphylococcus aureus (including methicillin-susceptible and methicillin-resistant strains), S. pyogenes, S. agalactiae, S. dysgalactiae, the S. anginosus group (including S. anginosus, S. intermedius, and S. constellatus), and Enterococcus faecalis (vancomycin susceptible strains) [FDA Label, F2356]. Dalbavancin acts by interfering with bacterial cell wall synthesis by binding to the D-alanyl-D-alanine terminus of nascent cell wall peptidoglycan and preventing cross-linking [FDA Label, F2356, A4072, A4073]. | |
| ATC Classification | J01XA04 | |
| IUPAC Name | None | |
| InChI | None | |
| Canonical SMILES | None | |
| Useful Links | DrugBank ChEBI PubChem Substance KEGG Drug ChemSpider Wikipedia ChEMBL | |
Interactions with
Dalbavancin
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