Basic Information
ID DDInter425
Drug Type small molecule
Molecular Formula C21H21F3IN3O2
Molecular Weight 531.318
CAS Number 934660-93-2
Description Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment of patients with unresectable or metastatic BRAF V600 mutation-positive melanoma.
ATC Classification L01EE02
IUPAC Name 1-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzoyl}-3-[(2S)-piperidin-2-yl]azetidin-3-ol
InChI BSMCAPRUBJMWDF-KRWDZBQOSA-N
Canonical SMILES OC1(CN(C1)C(=O)C1=C(NC2=C(F)C=C(I)C=C2)C(F)=C(F)C=C1)[C@@H]1CCCCN1
Useful Links DrugBank ChEBI PubChem Substance KEGG Drug ChemSpider BindingDB PharmGKB Wikipedia ChEMBL ZINC
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Multi-DRUG trade Multi-DRUG Drug type Warning Note