Drugs Information:
Aldesleukin
Basic Information
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| ID | DDInter38 | |
| Drug Type | biotech | |
| Protein Chemical Formula | C690H1115N177O202S6 | |
| Protein Average Weight | 15314.800 | |
| CAS Number | 110942-02-4 | |
| Description | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This recombinant form differs from native interleukin-2 in the following ways: a) Aldesleukin is not glycosylated because it is derived from E. coli; b) the molecule has no N-terminal alanine; the codon for this amino acid was deleted during the genetic engineering procedure; c) the molecule has serine substituted for cysteine at amino acid position 125. | |
| ATC Classification | L03AC01 | |
| Sequences | >Aldesleukin (CS373812.1 Sequence 2 from Patent EP1688146) MPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLE EELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNR WITFSQSIISTLT | |
| Useful Links | DrugBank PubChem Substance PharmGKB UniProtKB Therapeutic Targets Database Wikipedia ChEMBL | |
Interactions with
Aldesleukin
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