Basic Information
ID DDInter359
Drug Type small molecule
Molecular Formula C18H26ClN3
Molecular Weight 319.872
CAS Number 54-05-7
Description Chloroquine is an aminoquinolone derivative first developed in the 1940s for the treatment of malaria.[A191655] It was the drug of choice to treat malaria until the development of newer antimalarials such as [pyrimethamine], [artemisinin], and [mefloquine].[A191787] Chloroquine and its derivative [hydroxychloroquine] have since been repurposed for the treatment of a number of other conditions including HIV, systemic lupus erythematosus, and rheumatoid arthritis.[A192432] **The FDA emergency use authorization for [hydroxychloroquine] and chloroquine in the treatment of COVID-19 was revoked on 15 June 2020.[L14312]** Chloroquine was granted FDA Approval on 31 October 1949.[L12054]
ATC Classification P01BB52 P01BA01
IUPAC Name 7-chloro-N-[5-(diethylamino)pentan-2-yl]quinolin-4-amine
InChI WHTVZRBIWZFKQO-UHFFFAOYSA-N
Canonical SMILES CCN(CC)CCCC(C)NC1=CC=NC2=CC(Cl)=CC=C12
Useful Links DrugBank ChEBI PubChem Substance KEGG Compound KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Wikipedia ChEMBL
Interactions with Chloroquine
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Multi-DRUG trade Multi-DRUG Drug type Warning Note