2D 3D
	ID	DDInter257
	Drug Type	small molecule
	Molecular Formula	C11H16N2O3
	Molecular Weight	224.256
	CAS Number	77-26-9
	Description	Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervous system (CNS) depression that ranges from mild sedation to general anesthesia.[A177754] Butalbital has a low degree of selectivity and a narrow therapeutic index.[A177754] Typically indicated to manage tension (or muscle contraction) headaches, butalbital is often combined with one or more therapeutic agents, such as acetylsalicylic acid, acetaminophen, aspirin, and caffeine. There have not been clinical trials that evaluate the clinical efficacy of butalbital in migraines [A177754] thus it is not indicated for such condition. As with other barbiturates, butalbital carries a risk of abuse or misuse potential, intoxication, hangover, tolerance, dependence, and overdosage possibly leading to death.[L10370] Butalbital‐containing analgesics can also produce a drug‐induced headache in addition to tolerance and dependence. Due to these risks, the use of butalbital-containing combination products is typically limited for use only in cases where other medications are deemed ineffective and such usage is advised to be carefully monitored.[A177754]
	ATC Classification	N05CB01
IUPAC Name	5-(2-methylpropyl)-5-(prop-2-en-1-yl)-1,3-diazinane-2,4,6-trione
InChI	UZVHFVZFNXBMQJ-UHFFFAOYSA-N
Canonical SMILES	CC(C)CC1(CC=C)C(=O)NC(=O)NC1=O
Useful Links	DrugBank ChEBI PubChem Substance KEGG Drug ChemSpider PharmGKB Therapeutic Targets Database Wikipedia ChEMBL ZINC