Drugs Information:
Evolocumab
Basic Information
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| ID | DDInter2261 | |
| Drug Type | biotech | |
| Protein Chemical Formula | C6242H9648N1668O1996S56 | |
| Protein Average Weight | 141800.000 | |
| CAS Number | 1256937-27-5 | |
| Description | Evolocumab is a monoclonal antibody designed for the treatment of hyperlipidemia by Amgen. It is a subcutaneous injection approved by the FDA for individuals on maximum statin therapy who still require additional LDL-cholesterol lowering. It is approved for both homozygous and heterozygous familial cholesterolemia as an adjunct to other first-line therapies. Evolocumab is a human IgG2 monoclonal antibody that targets the proprotein convertase subtilisin/kexin type 9 (PCSK9). PCSK9 is a protein that targets LDL receptors for degradation, therefore reducing the liver's ability to remove LDL-cholesterol (LDL-C), or "bad" cholesterol, from the blood. Evolocumab is designed to bind to PCSK9 and inhibit PCSK9 from binding to LDL receptors on the liver surface, resulting in more LDL receptors on the surface of the liver to remove LDL-C from the blood. Evolocumab is the second PCSK9 inhibitor on the market, first being alirocumab. | |
| ATC Classification | C10AX13 | |
| Sequences | None | |
| Useful Links | DrugBank PubChem Substance KEGG Drug Wikipedia ChEMBL | |
Interactions with
Evolocumab
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Interactions with diseases
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Interactions with compound preparation
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