Drugs Information:
Tirzepatide
Basic Information
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| ID | DDInter2144 | |
| Drug Type | biotech | |
| Protein Chemical Formula | C225H348N48O68 | |
| Protein Average Weight | 4810.520 | |
| CAS Number | 2023788-19-2 | |
| Description | Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Dual GIP/GLP-1 agonists gained increasing attention as new therapeutic agents for glycemic and weight control as they demonstrated better glucose control and weight loss compared to selective GLP-1 receptor agonists in preclinical and clinical trials.[A246260] Tirzepatide comprises a 39 amino acid linear synthetic peptide conjugated to a C20 fatty diacid moiety.[A246260] Its protein sequence was based on the sequence of endogenous GIP, and its pharmacological action on GLP-1 receptors is comparable to endogenous GIP; however, the long half-life of tirzepatide allows for once-weekly dosing.[A246265] Tirzepatide was approved by the FDA on May 13, 2022, for the treatment of adults with type 2 diabetes, making it the first and only GIP and GLP-1 receptor agonist for this indication.[L41820] On September 15, 2022, tirzepatide was also approved by the European Commission.[L44386] | |
| ATC Classification | - | |
| Sequences | >Tirzepatide protein sequence YXEGTFTSDYSIXLDKIAQKAFVQWLIAGGPSSGAPPPS | |
| Useful Links | DrugBank Wikipedia | |
Interactions with
Tirzepatide
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