2D 3D
	ID	DDInter2116
	Drug Type	small molecule
	Molecular Formula	C23H16F7N5O2
	Molecular Weight	527.403
	CAS Number	1340593-59-0
	Description	Oteseconazole is an azole metalloenzyme inhibitor that targets fungal CYP51.[L41635] CYP51, also known as 14α demethylase, participates in the formation of ergosterol, a compound that plays a vital role in the integrity of cell membranes.[L41635,A247020] By binding and inhibiting CYP51, oteseconazole is active against most microorganisms associated with recurrent vulvovaginal candidiasis (RVVC).[L41635] Oteseconazole has demonstrated activity against _Candida albicans_, _Candida glabrata_, _Candida krusei_, _Candida parapsilosis_, _Candida tropicalis_, _Candida lusitaniae_ and _Candida dubliniensis_.[L41635] Unlike previous-generation azole antifungals, oteseconazole has a high selectivity for CYP51 and little interaction with human cytochrome P450s.[A247035] This is possible thanks to the tetrazole moiety in oteseconazole that increases target selectivity.[A247035] In contrast with oteseconazole, other antifungals with imidazole or triazole moieties, such as [ketoconazole] or [fluconazole], have a high number of drug-drug interactions due to their interaction with human CYPs.[A247050] The use of oteseconazole is contraindicated in females of reproductive potential due to its embryo-fetal toxicity risks.[L41635] This drug was approved by the FDA on April 26, 2022.[L41645]
	ATC Classification	J02AC06
IUPAC Name	(2R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-1,2,3,4-tetrazol-1-yl)-1-{5-[4-(2,2,2-trifluoroethoxy)phenyl]pyridin-2-yl}propan-2-ol
InChI	IDUYJRXRDSPPRC-NRFANRHFSA-N
Canonical SMILES	O[C@@](CN1C=NN=N1)(C1=CC=C(F)C=C1F)C(F)(F)C1=CC=C(C=N1)C1=CC=C(OCC(F)(F)F)C=C1
Useful Links	DrugBank ChEBI PubChem Substance ChemSpider BindingDB Wikipedia ChEMBL ZINC