Drugs Information:
Ropeginterferon alfa-2b
Basic Information
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| ID | DDInter2099 | |
| Drug Type | biotech | |
| Protein Chemical Formula | C16H29N3O6(C2H4O)n(C2H4O)n | |
| Protein Average Weight | 60000.000 | |
| CAS Number | 1335098-50-4 | |
| Description | Polycythemia vera (PV) is the most common Philadelphia chromosome-negative myeloproliferative neoplasm (MPN), characterized by increased hematocrit and platelet/leukocyte counts, an increased risk for hemorrhage and thromboembolic events, and a long-term propensity for myelofibrosis and leukemia.[A242000, A242005] [Interferon alfa-2b] has been used for decades to treat PV but requires frequent dosing and is not tolerated by all patients.[A242005] Ropeginterferon alfa-2b is a next-generation mono-pegylated type I interferon produced from proline-IFN-α-2b in _Escherichia coli_ that has high tolerability and a long half-life.[A242015, L39170] Ropeginterferon alfa-2b has shown efficacy in PV in _in vitro_ and _in vivo_ models and clinical trials.[A242010, A242015] Ropeginterferon alfa-2b was approved by the FDA on November 12, 2021, and is currently marketed under the trademark BESREMi by PharmaEssentia Corporation.[L39170] | |
| ATC Classification | L03AB15 | |
| Sequences | None | |
| Useful Links | DrugBank Wikipedia | |
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Ropeginterferon alfa-2b
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