2D 3D
	ID	DDInter2045
	Drug Type	small molecule
	Molecular Formula	C22H36O2
	Molecular Weight	332.528
	CAS Number	38398-32-2
	Description	Ganaxolone is the 3β-methylated synthetic analog of [allopregnanolone],[L41130] a metabolite of [progesterone].[A3197] Ganaxolone belongs to a class of compounds referred to as neurosteroids.[A3197] Endogenous neurosteroids, which comprise certain metabolites of progesterone and deoxycorticosterone, bind potently and specifically to GABAA receptors to enhance their inhibitory effects, and are thus known to have anxiolytic, analgesic, anticonvulsant, sedative, hypnotic, and anesthetic properties.[A245995] Ganaxolone, similar to its endogenous counterparts, is a positive allosteric modulator of GABAA receptors.[L41130] It was approved by the US FDA in March 2022 for the treatment of seizures associated with CDKL5 deficiency disorder (CDD), becoming the first FDA-approved treatment indicated specifically for CDD.[L41135]
	ATC Classification	N03AX27
IUPAC Name	1-[(1S,2S,5R,7S,10R,11S,14S,15S)-5-hydroxy-2,5,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl]ethan-1-one
InChI	PGTVWKLGGCQMBR-FLBATMFCSA-N
Canonical SMILES	[H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@](C)(O)CC[C@]12C
Useful Links	DrugBank PubChem Substance ChemSpider BindingDB Wikipedia ChEMBL ZINC