2D 3D
	ID	DDInter2044
	Drug Type	small molecule
	Molecular Formula	C21H22N4O3
	Molecular Weight	378.432
	CAS Number	1050477-31-0
	Description	Finerenone, or BAY 94-8862, is a mineralocorticoid receptor antagonist indicated to reduce the risk of sustained decline in glomerular filtration rate, end stage kidney disease, cardiovascular death, heart attacks, and hospitalization due to heart failure in adults with chronic kidney disease associated with type II diabetes mellitus.[A236519,L34739] Patients with kidney disease, would originally be given [spironolactone] or [eplerenone] to antagonize the mineraclocorticoid receptor.[A236544] Spironolactone has low selectivity and affinity for the receptor; it dissociates quickly and can also have effects at the androgen, progesterone, and glucocorticoid receptors.[A236544] Eplerenone is more selective and has longer lasting effects.[A236544] More selective nonsteroidal mineralocorticoid antagonists such as [apararenone], [esaxerenone], and finerenone were later developed.[A236544] So far, finerenone is the only nonsteroidal mineralocorticoid receptor antagonist to be FDA approved.[A236544,L34739] Finerenone was granted FDA approval on 9 July 2021,[L34739] followed by the EMA approval on 11 March 2022.[L41449]
	ATC Classification	C03DA05
IUPAC Name	(4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide
InChI	BTBHLEZXCOBLCY-QGZVFWFLSA-N
Canonical SMILES	CCOC1=NC=C(C)C2=C1[C@H](C1=CC=C(C=C1OC)C#N)C(C(N)=O)=C(C)N2
Useful Links	DrugBank ChemSpider Wikipedia ChEMBL