Basic Information
ID DDInter1971
Drug Type small molecule
Molecular Formula C8H8N2O3S
Molecular Weight 212.226
CAS Number 68291-97-4
Description Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This latter action may inhibit the uptake of the inhibitory neurotransmitter GABA while enhancing the uptake of the excitatory neurotransmitter glutamate.[L42530,L42535] Zonisamide represents an alternative for patients that remain refractory to established antiepileptic drugs. In 1989, it was approved for commercial use in Japan. The US and Europe approved it in 2000 and 2005, respectively.[A1379,A1383]
ATC Classification N03AX15 G01AE10
IUPAC Name (1,2-benzoxazol-3-yl)methanesulfonamide
InChI UBQNRHZMVUUOMG-UHFFFAOYSA-N
Canonical SMILES NS(=O)(=O)CC1=NOC2=CC=CC=C12
Useful Links DrugBank ChEBI PubChem Substance KEGG Compound KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Wikipedia ChEMBL ZINC
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