2D 3D
	ID	DDInter1933
	Drug Type	small molecule
	Molecular Formula	C6H11NO2
	Molecular Weight	129.157
	CAS Number	68506-86-5
	Description	Vigabatrin is an analog of gamma-aminobutyric acid ([GABA]), the main inhibitory neurotransmitter in the central nervous system, used in the treatment of refractory seizures and infantile spasms.[L13616] It irreversibly inhibits the enzyme responsible for GABA metabolism, thereby increasing levels of circulating GABA. Although administered as a racemic mixture, only the S(+) enantiomer is pharmacologically active.[A202037] It was first introduced as an antiepileptic agent in the United Kingdom in 1989 and was used extensively until 1997, when an association with vision loss became apparent.[A202124] Its use is now generally reserved for patients who have failed alternative therapies, and its US approval by the FDA in 2009 mandated the creation of a drug registry to monitor patients for visual deficits.[L13661,A202124]
	ATC Classification	N03AG04
IUPAC Name	4-aminohex-5-enoic acid
InChI	PJDFLNIOAUIZSL-UHFFFAOYSA-N
Canonical SMILES	NC(CCC(O)=O)C=C
Useful Links	DrugBank ChEBI PubChem Substance KEGG Compound KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Wikipedia ChEMBL