Basic Information
ID DDInter1913
Drug Type small molecule
Molecular Formula C8H16O2
Molecular Weight 144.211
CAS Number 99-66-1
Description Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton.[A178051] It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investigations into the anticonvulsant effects of khelline when he found that all of his samples, dissolved in valproic acid, exerted a similar degree of anticonvulsive activity. It first received approval on February 28, 1978 from the FDA under the trade name Depakene.[L6190] Since then, it has been investigated for neuroprotective, anti-manic, and anti-migraine effects. It is currently a compound of interest in the field of oncology for its anti-proliferative effects and is the subject of many clinical trials in a variety of cancer types.
ATC Classification N03AG01
IUPAC Name 2-propylpentanoic acid
InChI NIJJYAXOARWZEE-UHFFFAOYSA-N
Canonical SMILES CCCC(CCC)C(O)=O
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