Basic Information
ID DDInter1874
Drug Type small molecule
Molecular Formula C14H18N4O3
Molecular Weight 290.318
CAS Number 738-70-5
Description Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival.[L11893] Trimethoprim is often used in combination with [sulfamethoxazole] due to their complementary and synergistic mechanisms but may be used as a monotherapy in the treatment and/or prophylaxis of urinary tract infections.[L11893,L11830] It is structurally and chemically related to [pyrimethamine], another antifolate antimicrobial used in the treatment of plasmodial infections.[T707]
ATC Classification J01EE03 J01EA01 J04AM08 J01EE01 J01EE04 J01EE02 J01EE05 J01EE07
IUPAC Name 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
InChI IEDVJHCEMCRBQM-UHFFFAOYSA-N
Canonical SMILES COC1=CC(CC2=CN=C(N)N=C2N)=CC(OC)=C1OC
Useful Links DrugBank ChEBI PubChem Substance KEGG Compound KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Wikipedia ChEMBL ZINC
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