Basic Information
ID DDInter1864
Drug Type small molecule
Molecular Formula C6H18N4
Molecular Weight 146.234
CAS Number 112-24-3
Description Triethylenetatramine (TETA), also known as trientine, is a potent and selective copper (II)-selective chelator. It is a structural analog of linear polyamine compounds, [spermidine] and [spermine]. TETA was first developed in Germany in 1861 and its chelating properties were first recognized in 1925.[A19333] Initially approved by the FDA in 1985 as a second-line treatment for Wilson's disease,[A19334] TETA is currently indicated to treat adults with stable Wilson’s disease who are de-coppered and tolerant to [penicillamine].[L41730] TETA has been investigated in clinical trials for the treatment of heart failure in patients with diabetes.[A18804,A19332,A19333,A19334,A19335]
ATC Classification A16AX12
IUPAC Name (2-aminoethyl)({2-[(2-aminoethyl)amino]ethyl})amine
InChI VILCJCGEZXAXTO-UHFFFAOYSA-N
Canonical SMILES NCCNCCNCCN
Useful Links DrugBank ChEBI PubChem Substance KEGG Compound ChemSpider BindingDB Wikipedia ChEMBL ZINC
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