Basic Information
ID DDInter1829
Drug Type small molecule
Molecular Formula C14H11NO5
Molecular Weight 273.241
CAS Number 134308-13-7
Description Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication. It is a yellow, odorless, non-hygroscopic, crystalline compound. Tolcapone is associated with a risk of hepatotoxicity.
ATC Classification N04BX01
IUPAC Name 5-(4-methylbenzoyl)-3-nitrobenzene-1,2-diol
InChI MIQPIUSUKVNLNT-UHFFFAOYSA-N
Canonical SMILES CC1=CC=C(C=C1)C(=O)C1=CC(=C(O)C(O)=C1)[N+]([O-])=O
Useful Links DrugBank ChEBI PubChem Substance KEGG Compound KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Wikipedia ChEMBL ZINC
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Multi-DRUG trade Multi-DRUG Drug type Warning Note