Basic Information
ID DDInter1789
Drug Type small molecule
Molecular Formula C13H10N2O4
Molecular Weight 258.230
CAS Number 50-35-1
Description A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating the release of inflammatory mediators like tumor necrosis factor-alpha (TNF-a) and other cytokine action. Due to severe teratogenicity, pregnancy must be excluded before the start of treatment and patients must enrol in the THALIDOMID Risk Evaluation and Mitigation Strategy (REMS) program to ensure contraception adherence.[L41235]
ATC Classification L04AX02
IUPAC Name 2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
InChI UEJJHQNACJXSKW-UHFFFAOYSA-N
Canonical SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)C2=CC=CC=C12
Useful Links DrugBank ChEBI PubChem Substance KEGG Compound KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Wikipedia ChEMBL
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Multi-DRUG trade Multi-DRUG Drug type Warning Note