Basic Information
ID DDInter1783
Drug Type small molecule
Molecular Formula C22H24N2O8
Molecular Weight 444.435
CAS Number 60-54-8
Description Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane causing intracellular components to leak from bacterial cells. The FDA withdrew its approval for the use of all liquid oral drug products formulated for pediatric use containing tetracycline in a concentration greater than 25 mg/ml.[L43942] Other formulations of tetracycline continue to be used.
ATC Classification S02AA08 A02BD02 A01AB13 J01AA07 S01AA09 J01AA20 J01RA08 S03AA02 D06AA04 A02BD08
IUPAC Name (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
InChI OFVLGDICTFRJMM-WESIUVDSSA-N
Canonical SMILES [H][C@@]12C[C@@]3([H])C(=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C)C(=O)C1=C(O)C=CC=C1[C@@]3(C)O
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Interactions with Tetracycline
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