Basic Information
ID DDInter178
Drug Type small molecule
Molecular Formula C16H21Cl2N3O2
Molecular Weight 358.263
CAS Number 16506-27-7
Description Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
ATC Classification L01AA09
IUPAC Name 4-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-1,3-benzodiazol-2-yl}butanoic acid
InChI YTKUWDBFDASYHO-UHFFFAOYSA-N
Canonical SMILES CN1C(CCCC(O)=O)=NC2=CC(=CC=C12)N(CCCl)CCCl
Useful Links DrugBank ChEBI PubChem Substance KEGG Drug ChemSpider BindingDB Wikipedia ChEMBL ZINC
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