Basic Information
ID DDInter1771
Drug Type small molecule
Molecular Formula C12H9F3N2O2
Molecular Weight 270.207
CAS Number 163451-81-8
Description Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of hepatoxicity and teratogenicity for patients using teriflunomide.
ATC Classification L04AA31
IUPAC Name (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide
InChI UTNUDOFZCWSZMS-YFHOEESVSA-N
Canonical SMILES C\C(O)=C(/C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F
Useful Links DrugBank ChEBI PubChem Substance KEGG Drug ChemSpider BindingDB Wikipedia ChEMBL ZINC
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Multi-DRUG trade Multi-DRUG Drug type Warning Note