Basic Information
ID DDInter1747
Drug Type small molecule
Molecular Formula C15H19NO2
Molecular Weight 245.322
CAS Number 609799-22-6
Description Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset. By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon has been shown to improve sleep by resynchronizing the circadian rhythm through its "non-photic" mechanism. Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan drug status by the FDA in 2010.
ATC Classification N05CH03
IUPAC Name N-{[(1R,2R)-2-(2,3-dihydro-1-benzofuran-4-yl)cyclopropyl]methyl}propanamide
InChI PTOIAAWZLUQTIO-GXFFZTMASA-N
Canonical SMILES CCC(=O)NC[C@@H]1C[C@H]1C1=CC=CC2=C1CCO2
Useful Links DrugBank ChEBI PubChem Substance KEGG Drug ChemSpider Wikipedia ChEMBL ZINC
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