Basic Information
ID DDInter1739
Drug Type small molecule
Molecular Formula C24H28F3N3O3
Molecular Weight 463.501
CAS Number 106635-80-7
Description Tafenoquine is an 8-aminoquinoline analogue of primaquine which varies only on the presence of a 5-phenoxy group.[A35671, A35690] It was discovered by the scientists at the Walter Reed Army Institute of Research in 1978 as a substitute for primaquine that would be more effective against relapsing vivax malaria.[A35690] Tafenoquine was further developed collaboratively between GlaxoSmithKline and Medicines for Malaria Venture.[A35677] It was FDA approved on July 20, 2018.[L3770]
ATC Classification P01BA07
IUPAC Name N4-{2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl}pentane-1,4-diamine
InChI LBHLFPGPEGDCJG-UHFFFAOYSA-N
Canonical SMILES COC1=CC(C)=C2C(OC3=CC=CC(=C3)C(F)(F)F)=C(OC)C=C(NC(C)CCCN)C2=N1
Useful Links DrugBank ChEBI ChemSpider PharmGKB Wikipedia ChEMBL
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