Basic Information
ID DDInter1724
Drug Type small molecule
Molecular Formula C10H11N3O3S
Molecular Weight 253.278
CAS Number 723-46-6
Description Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria.[L11830] It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps in the biosynthesis of nucleic acids and proteins which are necessary for bacterial growth and division, and using them in conjunction helps to slow the development of bacterial resistance.[L11830] In this combination, sulfamethoxazole is useful for the treatment of a variety of bacterial infections, including those of the urinary, respiratory, and gastrointestinal tracts.
ATC Classification J04AM08 J01EE01 G01AE10 J01EC01
IUPAC Name 4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzene-1-sulfonamide
InChI JLKIGFTWXXRPMT-UHFFFAOYSA-N
Canonical SMILES CC1=CC(NS(=O)(=O)C2=CC=C(N)C=C2)=NO1
Useful Links DrugBank ChEBI PubChem Substance KEGG Compound KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Wikipedia ChEMBL ZINC
Interactions with Sulfamethoxazole
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Multi-DRUG trade Multi-DRUG Drug type Warning Note