2D 3D
	ID	DDInter1694
	Drug Type	small molecule
	Molecular Formula	Na2O9Si3Zr
	Molecular Weight	365.452
	CAS Number	17141-74-1
	Description	Sodium zirconium cyclosilicate is approved as the trade product Lokelma developed by AstraZeneca - an insoluble, non-absorbed sodium zirconium silicate, formulated as a powder for oral suspension that acts as a highly selective potassium removing agent.[L2933] It is administered orally and is odorless, tasteless, and stable at room temperature.[L2933] Approval of the medication is supported by data from three double-blind, placebo-controlled trials and two open-label trials which showed that the onset of action was approximately 1.0 hour and the median time to achieving normal potassium levels in the blood was 2.2 hours, with 92% of patients achieving normal potassium levels within 48 hours following administration.[L2933] The treatment effect was maintained for up to 12 months.[L2933]
	ATC Classification	V03AE10
IUPAC Name	disodium 1,3,5,2,4,6-trioxatrisilinane-2,2,4,4,6,6-hexakis(olate) zirconium
InChI	ARVUQMBOTBOHPL-UHFFFAOYSA-N
Canonical SMILES	[Na+].[Na+].[Zr].[O-][Si]1([O-])O[Si]([O-])([O-])O[Si]([O-])([O-])O1
Useful Links	DrugBank KEGG Drug Wikipedia