Basic Information
ID DDInter1690
Drug Type small molecule
Molecular Formula C4H7NaO3
Molecular Weight 126.087
CAS Number 502-85-2
Description Sodium oxybate (Xyrem) is a central nervous system (CNS) depressant used to treat cataplexy or excessive daytime sleepiness associated with narcolepsy.[L30598] It is a sodium salt of [gamma-Hydroxybutyric acid], an endogenous cerebral inhibitory neurotransmitter [A251445] and a metabolite of the inhibitory neurotransmitter GABA.[A251430] Due to its physiological effects, sodium oxybate is associated with a risk for substance misuse and abuse. Sodium oxybate has been misused to stimulate body growth and to induce euphoria, disinhibition, and sexual arousal as a "party drug" or "club drug."[A18723] For safety reasons, sodium oxybate is a controlled substance only available through a restricted program in approved countries.[L30598] An extended-release oral suspension formulation of sodium oxybate for narcolepsy, marketed under the brand name LUMRYZ, gained tentative FDA approval in July 2022. Its final approval is subject to a June 2023 patent expiry.[L42645] In some countries, sodium oxybate has been investigated and used in alcohol withdrawal syndrome (AWS) to aid abstinence maintenance in alcohol use disorders.[A251440, A251445]
ATC Classification N01AX11 N07XX04
IUPAC Name sodium 4-hydroxybutanoate
InChI XYGBKMMCQDZQOZ-UHFFFAOYSA-M
Canonical SMILES [Na+].OCCCC([O-])=O
Useful Links DrugBank PubChem Substance ChemSpider Wikipedia ChEMBL
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