Basic Information
ID DDInter1679
Drug Type small molecule
Molecular Formula C16H15F6N5O
Molecular Weight 407.314
CAS Number 486460-32-6
Description Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[Label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improve control of blood sugar[Label,A2255]. Sitagliptin was granted FDA approval on October 16, 2006[L6061].
ATC Classification A10BH51 A10BD24 A10BD07 A10BH01 A10BD12
IUPAC Name (3R)-3-amino-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
InChI MFFMDFFZMYYVKS-SECBINFHSA-N
Canonical SMILES N[C@@H](CC(=O)N1CCN2C(C1)=NN=C2C(F)(F)F)CC1=CC(F)=C(F)C=C1F
Useful Links DrugBank ChEBI PubChem Substance KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Wikipedia ChEMBL ZINC
Interactions with Sitagliptin
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Interactions with compound preparation
Multi-DRUG trade Multi-DRUG Drug type Warning Note