Basic Information
ID DDInter1649
Drug Type small molecule
Molecular Formula C7H11N3O3
Molecular Weight 185.183
CAS Number 3366-95-8
Description Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including [DB00916] and [DB00911], but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive and Gram-negative bacteria as well as protozoa.[A27210] Once it enters bacteria and parasites, secnidazole is activated by bacterial or parasitic enzymes to form a radical anion, thereby damaging and killing the target pathogen.[A245503] Secnidazole has been available in many other countries in Europe, Asia, South America, and Africa for decades.[A245503, A245508] In September 2017, FDA approved secnidazole under the market name Solosec for the treatment of trichomoniasis and bacterial vaginosis.[L39524]
ATC Classification P01AB07 J01RA07
IUPAC Name 1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol
InChI KPQZUUQMTUIKBP-UHFFFAOYSA-N
Canonical SMILES CC(O)CN1C(C)=NC=C1N(=O)=O
Useful Links DrugBank ChEBI PubChem Substance ChemSpider BindingDB Wikipedia ChEMBL
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