Basic Information
ID DDInter1637
Drug Type small molecule
Molecular Formula C14H10O5
Molecular Weight 258.226
CAS Number 552-94-3
Description Salsalate is a nonsteroidal anti-inflammatory agent for oral administration. Salsalate's mode of action as an anti-inflammatory and antirheumatic agent may be due to inhibition of synthesis and release of prostaglandins. The usefulness of salicylic acid, the active in vivo product of salsalate, in the treatment of arthritic disorders has been established. In contrast to aspirin, salsalate causes no greater fecal gastrointestinal blood loss than placebo. Salsalate is readily soluble in the small intestine where it is partially hydrolyzed to two molecules of salicylic acid. A significant portion of the parent compound is absorbed unchanged and undergoes rapid esterase hydrolysis in the body. The parent compound has an elimination half-life of about 1 hour. Salicylic acid (the active metabolite) biotransformation is saturated at anti-inflammatory doses of salsalate. Such capacity limited biotransformation results in an increase in the half-life of salicylic acid from 3.5 to 16 or more hours.
ATC Classification N02BA06
IUPAC Name 2-(2-hydroxybenzoyloxy)benzoic acid
InChI WVYADZUPLLSGPU-UHFFFAOYSA-N
Canonical SMILES OC(=O)C1=CC=CC=C1OC(=O)C1=CC=CC=C1O
Useful Links DrugBank ChEBI PubChem Substance KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Wikipedia ChEMBL ZINC
Interactions with Salsalate
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Interactions with compound preparation
Multi-DRUG trade Multi-DRUG Drug type Warning Note