Basic Information
ID DDInter162
Drug Type small molecule
Molecular Formula C10H12ClNO2
Molecular Weight 213.661
CAS Number 1134-47-0
Description Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients.[A245338] Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FDA in 1977.[A245323, A245338] Baclofen is used to manage severe muscle spasms of cerebral or spinal cord origins, including multiple sclerosis and traumatic brain injury.[L39429] Baclofen was investigated for use in alcohol dependence and withdrawal; however, evidence is limited and there is inconsistent evidence to suggest its clinical efficacy in managing alcohol dependence or withdrawal symptoms.[A173905, A173908, A245338]
ATC Classification M03BX01
IUPAC Name 4-amino-3-(4-chlorophenyl)butanoic acid
InChI KPYSYYIEGFHWSV-UHFFFAOYSA-N
Canonical SMILES NCC(CC(O)=O)C1=CC=C(Cl)C=C1
Useful Links DrugBank ChEBI PubChem Substance KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Guide to Pharmacology Wikipedia ChEMBL
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