Drugs Information:
Ribociclib
Basic Information
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ID | DDInter1588 | |
Drug Type | small molecule | |
Molecular Formula | C23H30N8O | |
Molecular Weight | 434.548 | |
CAS Number | 1211441-98-3 | |
Description | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced precision may play a role in ensuring that cancer cells do not continue to replicate uncontrollably. Ribociclib was approved by the U.S. FDA in March, 2017 as Kisqali. | |
ATC Classification | L01EF02 | |
IUPAC Name | 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide | |
InChI | RHXHGRAEPCAFML-UHFFFAOYSA-N | |
Canonical SMILES | CN(C)C(=O)C1=CC2=CN=C(NC3=CC=C(C=N3)N3CCNCC3)N=C2N1C1CCCC1 | |
Useful Links | DrugBank PubChem Substance KEGG Drug ChemSpider BindingDB PharmGKB Wikipedia ChEMBL ZINC |
Interactions with
Ribociclib
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