Basic Information
ID DDInter1527
Drug Type small molecule
Molecular Formula C20H24ClN3S
Molecular Weight 373.943
CAS Number 58-38-8
Description Prochlorperazine, also known as compazine, is a piperazine phenothiazine and first-generation antipsychotic drug that is used for the treatment of severe nausea and vomiting, as well as short-term management of psychotic disorders such as generalized non-psychotic anxiety and schizophrenia.[label] It mainly works by depressing the chemoreceptor trigger zone and blocking D2 dopamine receptors in the brain. It was shown to also block histaminergic, cholinergic and noradrenergic receptors.[L6637] Prochlorperazine was first developed in the 1950s [L6643] and was first approved by the FDA in 1956. Although newer antiemetic agents such as 5-HT3 antagonists are more heavily promoted, prochlorperazine is still widely used in nausea and vomiting.[L6640]
ATC Classification N05AB04
IUPAC Name 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
InChI WIKYUJGCLQQFNW-UHFFFAOYSA-N
Canonical SMILES CN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(Cl)C=C3)CC1
Useful Links DrugBank ChEBI PubChem Substance KEGG Compound KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Wikipedia ChEMBL ZINC
Interactions with Prochlorperazine
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Multi-DRUG trade Multi-DRUG Drug type Warning Note