Basic Information
ID DDInter1516
Drug Type small molecule
Molecular Formula C8H17NO2
Molecular Weight 159.226
CAS Number 148553-50-8
Description Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter.[A173995] It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions.[A187190] Although as per the FDA Label the mechanism of action has not been definitively defined, there is evidence that pregabalin exerts its effects by binding to the α2δ subunit of voltage-dependent calcium channels.[A187190][L7066] Pregabalin is marketed by Pfizer under the trade name Lyrica and Lyrica Cr (extended release).[L1006][L7066] It may have dependence liability if misused but the risk appears to be highest in patients with current or past substance use disorders.[A31161]
ATC Classification N03AX16
IUPAC Name (3S)-3-(aminomethyl)-5-methylhexanoic acid
InChI AYXYPKUFHZROOJ-ZETCQYMHSA-N
Canonical SMILES CC(C)C[C@H](CN)CC(O)=O
Useful Links DrugBank ChEBI PubChem Substance KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Wikipedia ChEMBL ZINC
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