Basic Information
ID DDInter150
Drug Type small molecule
Molecular Formula C9H7N7O2S
Molecular Weight 277.263
CAS Number 446-86-6
Description Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection.[L11214] Azathiprine was granted FDA approval on 20 March 1968.[L11214]
ATC Classification L04AX01
IUPAC Name 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-7H-purine
InChI LMEKQMALGUDUQG-UHFFFAOYSA-N
Canonical SMILES CN1C=NC(=C1SC1=NC=NC2=C1NC=N2)[N+]([O-])=O
Useful Links DrugBank ChEBI PubChem Substance KEGG Compound KEGG Drug ChemSpider BindingDB PharmGKB Therapeutic Targets Database Wikipedia ChEMBL ZINC
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