Basic Information
ID DDInter1477
Drug Type small molecule
Molecular Formula C12H11NO
Molecular Weight 185.222
CAS Number 53179-13-8
Description Pirfenidone is a synthetic pyridone drug.[A251370] It is an antifibrotic agent with anti-inflammatory and antioxidant properties [A251370] that is used to treat idiopathic pulmonary fibrosis (IPF),[L26801] which is a chronic, progressive form of interstitial pneumonia.[A251370] While its mechanism of action is not yet fully understood, pirfenidone is proposed to primarily regulate tumor necrosis factor (TNF) pathways and modulate cellular oxidation.[A251365] The FDA first approved pirfenidone alongside [nintedanib] as one of the first drugs to treat IPF.[A251165]
ATC Classification L04AX05
IUPAC Name 5-methyl-1-phenyl-1,2-dihydropyridin-2-one
InChI ISWRGOKTTBVCFA-UHFFFAOYSA-N
Canonical SMILES CC1=CN(C(=O)C=C1)C1=CC=CC=C1
Useful Links DrugBank ChEBI PubChem Substance ChemSpider BindingDB Wikipedia ChEMBL ZINC
Interactions with Pirfenidone
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Multi-DRUG trade Multi-DRUG Drug type Warning Note